Essential oil from leaves of Myrciaria floribunda (H. West ex Willd.) O. Berg has antinociceptive and anti-inflammatory potential.
Priscilla Glazielly Dos Santos de MoraesIzabelly Bianca da Silva SantosValquíria Bruna Guimarães SilvaJúlio César Ribeiro Dede Oliveira FariasAguiarDaniela Maria do Amaral Ferraz NavarroAlisson Macário de OliveiraMaria Tereza Dos Santos CorreiaWêndeo Kennedy CostaMárcia Vanusa da SilvaPublished in: Inflammopharmacology (2023)
Myrciaria floribunda is a plant that is distributed across different Brazilian biomes such as the Amazon, Caatinga, Cerrado, and Atlantic Forest, and it possesses antioxidant, antimicrobial, and anticancer properties. The antinociceptive and anti-inflammatory properties of the essential oil from M. floribunda leaves (MfEO) were examined in this study using mouse models. Gas chromatography-mass spectrometry was employed to describe the oil, and the results revealed that δ-cadinene, bicyclogermacrene, α-cadinol, and epi-α-muurolol predominated in the chemical profile. The oil stimulated a decrease in nociception in the chemical and thermal models used to evaluate acute antinociceptive activity. Findings from the use of pain pathway blockers to study the presumed underlying mechanism indicated opioid pathway activity. The anti-edematogenic effect, decreased cell migration, and generation of pro-inflammatory cytokines provided evidence of the anti-inflammatory potential of the essential oil from M. floribunda. According to this research, the essential oil from M. floribunda can effectively alleviate acute pain and inflammation.
Keyphrases
- essential oil
- anti inflammatory
- chronic pain
- cell migration
- pain management
- gas chromatography mass spectrometry
- liver failure
- respiratory failure
- neuropathic pain
- mouse model
- drug induced
- oxidative stress
- aortic dissection
- staphylococcus aureus
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome