Role of pentamer complex-specific and IgG subclass 3 antibodies in HCMV hyperimmunoglobulin and standard intravenous IgG preparations.
Matthias Stefan SchamperaJose Arellano-GalindoKarl Oliver KaganStuart P AdlerGerhard JahnKlaus HamprechtPublished in: Medical microbiology and immunology (2018)
Via specific antibody depletion, we could demonstrate that pentameric complex-specific antibodies are present in HIG and bind to the recombinant PC resulting in a highly significant reduction of NT-capacity compared to the UL130 TAN-and SWS-peptides. We could not confirm the functional role of IgG subclass 3 neutralizing antibodies in IgG-preparations.
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