DYRK1A reinforces epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via cooperatively activating STAT3 and SMAD.

Yang-Ling LiMan-Man ZhangLin-Wen WuYe-Han LiuZuo-Yan ZhangLing-Hui ZengNeng-Ming LinChong Zhang

Published in: Journal of biomedical science (2022)

Overall, the present study not only uncovered the promoting effect of DYRK1A on HCC metastasis and revealed the mechanism but also provided a new approach to predict and treat metastatic HCC.

Keyphrases

epithelial mesenchymal transition
transforming growth factor
signaling pathway
squamous cell carcinoma
small cell lung cancer
cell proliferation
single cell