A DNA origami nanostructure embedded with NQO1-activated prodrugs for precision drug delivery.

Zhimei HeWenjie XiangQin FanLian-Hui Wang Jie Chao

Published in: Chemical communications (Cambridge, England) (2023)

A rectangle DNA origami nanostructure equipped with doxorubicin-derived prodrugs targeting a tumor cell-specific enzyme (NQO1) is constructed. Combining the high prodrug payload of DNA origami and NQO1-activated chemotherapy, this nanosystem presents therapeutic selectivity for NQO1-overexpressing MCF-7 cells over healthy L02 cells, offering a potent strategy for precision cancer therapy.

Keyphrases

cancer therapy
drug delivery
induced apoptosis
circulating tumor
cell cycle arrest
cell free
single molecule
endoplasmic reticulum stress
single cell
drug release
signaling pathway
cell death
cell therapy
squamous cell carcinoma
stem cells
mesenchymal stem cells
breast cancer cells
bone marrow