Intravenous Thrombolysis for Acute Ischemic Stroke in Patients With Recent Direct Oral Anticoagulant Use: A Systematic Review and Meta-Analysis.

Malik GhannamMohammad AlMajaliMilagros Galecio-Castillo Abdullah Al QudahFarid KhasiyevMahmoud DibasDana GhazalehJuan Vivanco-SuarezCristian Morán-MariñosMudassir Farooqui Aaron Rodriguez Calienes Prateeka Koul Hannah RoederHyungSub ShimEdgar A Samaniego Enrique C Leira Harold P Adams Santiago Ortega Gutierrez

Published in: Journal of the American Heart Association (2023)

Patients with acute ischemic stroke treated with IVT in recent DOAC versus non-DOAC use have similar rates of hemorrhagic complications and functional independence. Further prospective randomized trials are warranted.

Keyphrases

acute ischemic stroke
direct oral anticoagulants
venous thromboembolism
atrial fibrillation
high dose
low dose
newly diagnosed
pulmonary embolism