Loss of VAMP5 in mice results in duplication of the ureter and insufficient expansion of the lung.
Maiko IkezawaYuki TajikaHitoshi UenoTohru MurakamiNaokazu InoueHiroshi YorifujiPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2018)
VAMP5 KO mice showed a low birth rate and abnormalities of the urinary and respiratory systems. VAMP5 KO mice died around birth, possibly due to defects in vesicoureteral flow and breathing. The results presented could provide a basis for future studies to understand the roles of VAMP5 protein. Developmental Dynamics 247:754-762, 2018. © 2018 Wiley Periodicals, Inc.