LDL-c Lowering, Ischemic Stroke, and Small Vessel Disease Brain Imaging Biomarkers: A Mendelian Randomization Study.

Marie-Joe Dib Loukas ZagkosDevendra MeenaStephen BurgessJulio Alonso Chirinos Dipender Gill

Published in: Stroke (2024)

This study provides supporting evidence of a potentially protective effect of LDL-c lowering through NPC1L1 inhibition on perivascular space and SVS risk, highlighting novel therapeutic targets for SVS.

Keyphrases

high resolution
atrial fibrillation
resting state
mass spectrometry
functional connectivity
low density lipoprotein