Protective effect of phenolic acids from Chebulae Fructus immaturus on carbon tetrachloride induced acute liver injury via suppressing oxidative stress, inflammation and apoptosis in mouse.
Nan LiBin LiJiashu ZhangXinguang LiuJing LiuKun LiTaowen PanShouyu WangYunpeng DiaoPublished in: Natural product research (2019)
Chebulae Fructus immaturus, a traditional Tibetan medicine, originated from the immature fruit of Terminalia chebula Retz., has been proven to have antioxidat function. However, its protection to injury liver cell caused by carbon tetrachloride (CCl4) has not been clarified. This study evaluated the effect of phenolic acid from Chebulae Fructus immaturus (PATC) on CCl4-induced acute liver injury in mice and related molecular mechanisms. Our data showed that PATC had convincing protective effects on the CCl4-induced acute liver injury by enhancing the anti-oxidative defense system, ameliorating inflammation and inhibiting the hepatocyte apoptosis.
Keyphrases
- liver injury
- oxidative stress
- drug induced
- diabetic rats
- ischemia reperfusion injury
- dna damage
- induced apoptosis
- signaling pathway
- endoplasmic reticulum stress
- single cell
- cell therapy
- electronic health record
- big data
- high fat diet induced
- heat shock
- stem cells
- type diabetes
- metabolic syndrome
- skeletal muscle
- mesenchymal stem cells
- liver fibrosis