Association Between Proton Pump Inhibitor Use and Extended-Spectrum Beta-Lactamase Urinary Tract Infection in Adults: A Retrospective Study.
Nishan Kunnummal PurayilVamanjore Aboobaker NaushadPrem ChandraPrakash JosephZahida KhalilMuhammad ZahidGodwin WilsonMuhammed Kunhi KayakkoolBasma AyariSajid ChalihadanEmad Bashier I ElmagboulSanjay H DoiphodePublished in: Infection and drug resistance (2023)
Exposure to PPIs in the preceding 3 months showed an association with increased risk of ESBL-UTI. While Esomeprazole showed a positive association, Lansoprazole had an inverse association for ESBL-UTI. Restricting the use of PPIs may be beneficial in the fight against antimicrobial resistance.