Differentiation-Promoting Effects of Okeaniamides A and B from an Okeania sp. Marine Cyanobacterium on Preadipocytes.
Kaori OzakiYuka AsatoNoriyuki NatsumeShunya TojoShimpei SumimotoArihiro IwasakiKiyotake SuenagaToshiaki TeruyaPublished in: Journal of natural products (2023)
The linear lipopeptides okeaniamide A ( 1 ) and okeaniamide B ( 2 ) were isolated from an Okeania sp. marine cyanobacterium collected in Okinawa. The structures of these compounds were established by spectroscopic analyses, and the absolute configurations were elucidated based on a combination of chemical degradations, Marfey's analysis, and derivatization reactions. Okeaniamide A ( 1 ) and okeaniamide B ( 2 ) dose-dependently promoted the differentiation of mouse 3T3-L1 preadipocytes in the presence of insulin.
Keyphrases
- type diabetes
- ms ms
- molecular docking
- high resolution
- liquid chromatography
- liquid chromatography tandem mass spectrometry
- high performance liquid chromatography
- gas chromatography mass spectrometry
- simultaneous determination
- skeletal muscle
- glycemic control
- high resolution mass spectrometry
- molecular dynamics simulations