Treatment failure in a UK malaria patient harbouring genetically variant Plasmodium falciparum from Uganda with reduced in vitro susceptibility to artemisinin and lumefantrine.
Donelly A van SchalkwykSade PrattDebbie NolderLindsay B StewartHelen LiddyJulian Muwanguzi-KarugabaKhalid B BeshirDawn BrittenEmma VictoryClaire RogersJames MillardMichael BrownLaura E NabarroAndrew TaylorBernadette C YoungPeter L ChiodiniColin J SutherlandPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2023)
We confirm, in a documented case of artemether-lumefantrine treatment failure imported from Uganda, the presence of pfk13 mutations encoding L145V and A675V. Parasites with reduced susceptibility to both artemisinin and lumefantrine may be emerging in Uganda.