Confounding Effects of Tamoxifen: Cautionary and Practical Considerations for the Use of Tamoxifen-Inducible Mouse Models in Atherosclerosis Research.
Allison M DubnerSizhao LuAustin J JollyTysen NobleTyler HinthornRaphael A NemenoffKaren S MoultonMark W MajeskyMary C M Weiser-EvansPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
In this study, we establish that tamoxifen administration results in decreased serum cholesterol, decreased plaque formation, and increased hepatic lipid accumulation. These alterations represent significant confounding variables in atherosclerosis research, and we urge future investigators to take these findings into consideration when planning and executing their own atherosclerosis experiments.