Drug Molecular Immobilization and Photofunctionalization of Calcium Phosphates for Exploring Theranostic Functions.
Iori YamadaKota ShibaTania Guadalupe Peñaflor GalindoMotohiro TagayaPublished in: Molecules (Basel, Switzerland) (2022)
Theranostics (bifunction of therapeutics and diagnostics) has attracted increasing attention due to its efficiency that can reduce the physical and financial burden on patients. One of the promising materials for theranostics is calcium phosphate (CP) and it is biocompatible and can be functionalized not only with drug molecules but also with rare earth ions to show photoluminescence that is necessary for the diagnostic purpose. Such the CP-based hybrids are formed in vivo by interacting between functional groups of organic molecules and inorganic ions. It is of great importance to elucidate the interaction of CP with the photofunctional species and the drug molecules to clarify the relationship between the existing state and function. Well-designed photofunctional CPs will contribute to biomedical fields as highly-functional ormultifunctional theranostic materials at the nanoscales. In this review, we describe the hybridization between CPs and heterogeneous species, mainly focusing on europium(III) ion and methylene blue molecule as the representative photofunctional species for theranostics applications.
Keyphrases
- quantum dots
- end stage renal disease
- water soluble
- photodynamic therapy
- ejection fraction
- newly diagnosed
- chronic kidney disease
- physical activity
- adverse drug
- fluorescence imaging
- working memory
- peritoneal dialysis
- drug induced
- mental health
- healthcare
- genetic diversity
- small molecule
- aqueous solution
- drug delivery
- risk factors
- mass spectrometry
- liquid chromatography