Rh-Catalyzed Anti-Markovnikov Hydrocyanation of Terminal Alkynes.

Published in: Journal of the American Chemical Society (2017)

We report the first highly stereo- and regioselective hydrocyanation of terminal alkynes to furnish E-configured alkenyl nitriles. Acrylonitriles can be accessed on gram scale with broad substrate scope and functional group tolerance. The hydrocyanation reaction employs acetone cyanohydrin as a practical alternative to HCN gas.

Keyphrases

room temperature
gram negative
structural basis