Repeated Yueju, But Not Fluoxetine, Induced Sustained Antidepressant Activity in a Mouse Model of Chronic Learned Helplessness: Involvement of CaMKII Signaling in the Hippocampus.

Zhilu Zou Jiaru Huang Qingqing Yang Yuxuan Zhang Bo Xu Ping Wang Gang Chen

Published in: Evidence-based complementary and alternative medicine : eCAM (2022)

These findings showed the sustained antidepressant efficacy of chronic treatment with routine dose of Yueju and the CaMKII signaling activation may play a critical role in the sustained antidepressant response.

Keyphrases

major depressive disorder
mouse model
drug induced
bipolar disorder
clinical practice
combination therapy
blood brain barrier
brain injury