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bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM)-the active metabolite of the laxatives bisacodyl and sodium picosulfate-enhances contractility and secretion in human intestine in vitro.

D KruegerI E DemirG O CeyhanF ZellerMichael Schemann
Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2018)
BHPM enhanced mucosal secretion and muscle contractility. Results suggested that the laxative effect of BHPM was a consequence of the increase in muscle tone as well as an increased K+ secretion when acting luminally and a nerve-driven Cl- and HCO3- secretion once acting basolaterally after absorption.
Keyphrases
  • skeletal muscle
  • endothelial cells
  • smooth muscle
  • induced pluripotent stem cells