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Immunohistochemical markers informing the diagnosis of sebaceous carcinoma and its distinction from its mimics: Adipophilin and factor XIIIa to the rescue?

Michael T Tetzlaff
Published in: Journal of cutaneous pathology (2019)
Sebaceous carcinoma typically presents a diagnostic challenge because it mimics other more common, locally invasive carcinomas, including squamous cell carcinoma and basal cell carcinoma-particularly when one of these tumors exhibits concomitant clear-cell changes. Immunohistochemical studies offering high sensitivity and specificity are critical for accurate diagnosis.
Keyphrases
  • basal cell carcinoma
  • squamous cell carcinoma
  • clear cell
  • high resolution
  • mass spectrometry
  • lymph node metastasis
  • case control
  • locally advanced
  • structural basis