The Burden of Cancer and Pre-cancerous Conditions Among Transgender Individuals in a Large Healthcare Network.
Shuang YangYongqiu LiChristopher W WheldonMattia ProsperiThomas J GeorgeElizabeth A ShenkmanFei WangJiang BianYi GuoPublished in: medRxiv : the preprint server for health sciences (2024)
The current study aimed to examine the prevalence of and risk factors for cancer and pre-cancerous conditions, comparing transgender and cisgender individuals, using 2012-2023 electronic health record data from a large healthcare system. We identified 2,745 transgender individuals using a previously validated computable phenotype and 54,900 matched cisgender individuals. We calculated the prevalence of cancer and pre-cancer related to human papillomavirus (HPV), human immunodeficiency virus (HIV), tobacco, alcohol, lung, breast, colorectum, and built multivariable logistic models to examine the association between gender identity and the presence of cancer or pre-cancer. Results indicated similar odds of developing cancer across gender identities, but transgender individuals exhibited significantly higher risks for pre-cancerous conditions, including alcohol-related, breast, and colorectal pre-cancers compared to cisgender women, and HPV-related, tobacco-related, alcohol-related, and colorectal pre-cancers compared to cisgender men. These findings underscore the need for tailored interventions and policies addressing cancer health disparities affecting the transgender population.
Keyphrases
- papillary thyroid
- human immunodeficiency virus
- healthcare
- squamous cell
- hiv testing
- risk factors
- squamous cell carcinoma
- hepatitis c virus
- public health
- lymph node metastasis
- type diabetes
- metabolic syndrome
- antiretroviral therapy
- machine learning
- adipose tissue
- deep learning
- hiv aids
- insulin resistance
- health information
- high grade
- smoking cessation
- south africa
- artificial intelligence