Increased Death of Peripheral Blood Mononuclear Cells after TLR4 Inhibition in Sepsis Is Not via TNF/TNF Receptor-Mediated Apoptotic Pathway.

Chien-Ming ChuLi-Chung ChiuChung-Chieh YuLi-Pang ChuangKuo-Chin KaoLi-Fu LiHuang-Ping Wu

Published in: Mediators of inflammation (2021)

The apoptosis did not decrease, while TLR4 was inhibited. After TLR4 inhibition, there was an unknown mechanism to keep cell death in stimulated PBMCs in patients with sepsis.

Keyphrases

cell death
toll like receptor
inflammatory response
cell cycle arrest
immune response
rheumatoid arthritis
acute kidney injury
intensive care unit
septic shock
nuclear factor
signaling pathway