The time-dependent variation of ATP release in mouse primary-cultured urothelial cells is regulated by the clock gene.
Tatsuya IharaTakahiko MitsuiYuki NakamuraMie KandaSachiko TsuchiyaSatoru KiraHiroshi NakagomiNorifumi SawadaManabu KamiyamaEiji ShigetomiYouichi ShinozakiMitsuharu YoshiyamaAtsuhito NakaoMasayuki TakedaSchuichi KoizumiPublished in: Neurourology and urodynamics (2018)
ATP release in the bladder urothelium induces SBF and may have a circadian rhythm regulated by the clock genes. In the bladder urothelium, clock gene abnormalities may disrupt circadian ATP release by inducing Piezo1, TRPV4, VNUT, and Cx26. All these genes can trigger nocturia.
Keyphrases
- genome wide identification
- genome wide
- spinal cord injury
- urinary tract
- genome wide analysis
- induced apoptosis
- copy number
- dna methylation
- transcription factor
- cell cycle arrest
- high grade
- endothelial cells
- neuropathic pain
- bioinformatics analysis
- oxidative stress
- gene expression
- signaling pathway
- blood pressure
- endoplasmic reticulum stress