Extracellular Signal-Regulated Kinase 5 Regulates the Malignant Phenotype of Cholangiocarcinoma Cells.

Alessandra GentiliniGiulia LoriAlessandra CaligiuriChiara RaggiGiovanni Di MairaMirella PastoreBenedetta PiombantiTiziano LottiniAnnarosa ArcangeliStefania MadiaiNadia NavariJesus M BanalesSabina Di MatteoDomenico AlvaroLea DuweJesper B AndersenAlessandro TubitaIgnazia TusaLuca Di TommasoClaudia CampaniElisabetta RovidaFabio Marra

Published in: Hepatology (Baltimore, Md.) (2021)

ERK5 is a key mediator of growth and migration of CCA cells and supports a protumorigenic crosstalk between the tumor and the microenvironment.

Keyphrases

induced apoptosis
cell cycle arrest
signaling pathway
endoplasmic reticulum stress
stem cells
cell proliferation