Multisite mpox infection and viral dynamics among persons with HIV in metro-Atlanta.
Gregory L DamhorstAyako Wendy FujitaEric FittsBrittany SzaboHeather B BowersCourtney SabinoAlaa AhmedEthan WangPardis SabetiKaleb McLendonJulie SullivanMorgan N GreenleafDivine McCaslinMelody PalmoreAlbert M AndersonBruce AldredClifford GunthelGreg S MartinJonathan A ColasantiWilbur A LamLeda C BassitAnuradha RaoAnandi N ShethBoghuma K TitanjiPublished in: The Journal of infectious diseases (2023)
The 2022 mpox outbreak primarily involved sexual transmission among men who have sex with men and disproportionately affected persons with HIV (PWH). We examined viral dynamics and clinical features in a cohort evaluated for mpox infection at a comprehensive HIV clinic in Atlanta, Georgia. Viral DNA was found in 8 oropharyngeal and 5 anorectal specimens among 10 mpox cases confirmed by lesion swab PCR. Within-participant anatomic site of lowest Ct value varied, and lower Ct values were found in oropharyngeal and anorectal swabs when corresponding symptoms were present. This provides insight into mpox infection across multiple anatomic sites among PWH.
Keyphrases
- hiv testing
- men who have sex with men
- hiv positive
- antiretroviral therapy
- sars cov
- hiv infected
- human immunodeficiency virus
- south africa
- hepatitis c virus
- hiv aids
- computed tomography
- image quality
- contrast enhanced
- magnetic resonance imaging
- single molecule
- mental health
- physical activity
- cell free
- nucleic acid
- pet ct