Adiponectin overexpression promotes fracture healing through regulating the osteogenesis and adipogenesis balance in osteoporotic mice.

Ju ZhangShibo LiuZe HeHanghang LiuYao LiuPei HuZhongming LiJiazhuang XuEn Luo

Published in: Journal of bone and mineral metabolism (2023)

We demonstrated that APN overexpression facilitates bone fracture healing in osteoporosis. Furthermore, APN overexpression promoted bone formation in OVX mouse BMSCs and bone fracture ends by regulating the balance between osteogenesis and adipogenesis both in vitro and in vivo.

Keyphrases

bone mineral density
bone regeneration
cell proliferation
high fat diet induced
postmenopausal women
transcription factor
hip fracture
insulin resistance
body composition
metabolic syndrome
soft tissue
type diabetes
bone loss
skeletal muscle