Association of disease course and brain structural alterations in major depressive disorder.
Hannah LemkeLina RomankiewiczKatharina FörsterSusanne MeinertLena WaltemateStella M FingasDominik GrotegerdRonny RedlichKatharina DohmElisabeth Johanna LeehrKatharina ThielVerena EnnekingKatharina BroschTina MellerKai RingwaldSimon SchmittFrederike SteinOlaf SteinsträterJochen BauerWalter HeindelAndreas JansenAxel KrugIgor NenadicTilo KircherUdo DannlowskiPublished in: Depression and anxiety (2022)
This study shows that a more severe and chronic lifetime disease course in MDD is associated with reduced volume in brain regions relevant for executive and cognitive functions and emotion regulation in a large sample of patients representing the broad heterogeneity of MDD disease course. These findings were only partly influenced by other clinical characteristics (e.g., remission status, psychopharmacological treatment).
Keyphrases
- major depressive disorder
- bipolar disorder
- end stage renal disease
- newly diagnosed
- white matter
- resting state
- chronic kidney disease
- peritoneal dialysis
- single cell
- working memory
- rheumatoid arthritis
- functional connectivity
- brain injury
- systemic lupus erythematosus
- multiple sclerosis
- blood brain barrier
- ulcerative colitis
- patient reported