Ex vivo enrichment of PRAME antigen-specific T cells for adoptive immunotherapy using CD137 activation marker selection.

Koon H LeeKavitha GowrishankarJanine StreetHelen Marie McGuireFabio LucianiBrendan HughesMandeep SinghLeighton E ClancyDavid J GottliebKenneth P MicklethwaiteEmily Blyth

Published in: Clinical & translational immunology (2020)

PRAME-specific T cells for adoptive immunotherapy were enriched from healthy donor mononuclear cells. The products were oligoclonal, exhibited Th1 phenotype and produced multiple cytokines.

Keyphrases

cell therapy
induced apoptosis
cell cycle arrest
peripheral blood
stem cells
endoplasmic reticulum stress
nk cells
cell proliferation
bone marrow