Pleiotropy of systemic lupus erythematosus risk alleles and cardiometabolic disorders: A phenome-wide association study and inverse-variance weighted meta-analysis.

Vivian K KawaiMingjian ShiGe LiuQiPing FengWeiQi WeiCecilia P ChungTheresa L WalunasAdam S GordonJames G LinnemanScott J HebbringJohn B HarleyNancy J CoxDan M RodenC Michael SteinJonathan D Mosley

Published in: Lupus (2021)

A weighted GRS for SLE was associated with an increased risk of several autoimmune-related phenotypes including type I diabetes but not with cardiometabolic disorders.

Keyphrases

systemic lupus erythematosus
systematic review
disease activity
magnetic resonance
type diabetes
contrast enhanced
network analysis
meta analyses
multiple sclerosis
rheumatoid arthritis
glycemic control
computed tomography
metabolic syndrome
skeletal muscle
case control