Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity.

Khalid W KalimJun-Qi YangMark WunderlichVishnu ModurPhuong NguyenYuan LiTing WenAshley Kuenzi DavisRavinder VermaQing Richard LuAnil G JeggaYi ZhengFukun Guo

Published in: Journal for immunotherapy of cancer (2022)

Rational targeting of Cdc42 in Treg cells holds therapeutic promises in cancer immunotherapy.

Keyphrases

regulatory t cells
induced apoptosis
dendritic cells
cancer therapy
cell cycle
cell cycle arrest
immune response
cell proliferation