KA-mediated excitotoxicity induces neuronal ferroptosis through activation of ferritinophagy.

Yi-Yue JiangWei-Long WuJia-Ni HuangNa LiuJing WangXiao-Rui WanZheng-Hong QinYan Wang

Published in: CNS neuroscience & therapeutics (2024)

KA-induced excitotoxicity activates ferritinophagy, and targeting ferritinophagy effectively inhibits downstream ferroptosis. Interference with NCOA4 effectively attenuates KA-induced neuronal damage. This study provides a potential therapeutic target for excitotoxicity related disease conditions.

Keyphrases

high glucose
cell death
diabetic rats
oxidative stress
drug induced
endothelial cells
climate change
brain injury
blood brain barrier
human health