A meta-analysis and a functional study support the influence of mtDNA variant m.16519C on the risk of rapid progression of knee osteoarthritis.
Alejandro Durán-SotuelaMercedes Fernandez-MorenoVictoria Suárez-UlloaJorge Vázquez-GarcíaSara RelañoTamara Hermida-GómezVanesa Balboa-BarreiroLucia Lourido-SalasValentina CalamiaPatricia Fernandez-PuenteCristina Ruiz-RomeroJuan Fernández-TajesCarlos Vaamonde-GarcíaMaría C de AndrésNatividad OreiroFrancisco Javier BlancoIgnacio Rego PerezPublished in: Annals of the rheumatic diseases (2023)
The presence of the mtDNA variant m.16519C increases the risk of rapid progression of knee OA. Among the most modulated biological processes associated with this variant, inflammation and negative regulation of cellular process stand out. The design of therapies based on the maintenance of mitochondrial function is recommended.