A role for translational regulation by S6 kinase and a downstream target in inflammatory pain.

June Bryan de la PeñaNikesh KunderTzu-Fang LouRebecca ChaseAlexander D StanowickPaulino Barragan-IglesiasJoseph J PancrazioZachary T Campbell

Published in: British journal of pharmacology (2021)

Our data show a novel role of S6K1 in modulating the rapid response to inflammatory mediators, with c-Fos being one key downstream target. Targeting the S6 kinase pathway or c-Fos is an exciting new avenue for pain-modulating compounds.

Keyphrases

chronic pain
pain management
neuropathic pain
oxidative stress
signaling pathway
protein kinase
tyrosine kinase
electronic health record
cancer therapy
spinal cord
machine learning
spinal cord injury