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Is deep brain involvement in intracranial primary central nervous system lymphoma of importance for penetration of chemotherapeutic agents?

Torstein Ragnar MelingAnna LatyshevaMichele Da BroiGuro JahrHarald HolteKlaus BeiskeKyrre Eeg Emblem
Published in: Neuroradiology (2018)
In intracranial PCNSL, the only significant prognostic factor for OS and PFS in multivariate analysis was age and deep brain involvement. While contingent on a small study sample, we hypothesize this may in part be explained by regional differences in vascular supply and delivery from a dysfunctional perfusion signature.
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