Correlation between serum IGF-1 and EGF levels and neuropsychiatric and cognitive in Parkinson's disease patients.

Xiaoxue ShiJinhua ZhengJian Jun MaDongsheng LiQi GuSiyuan ChenZhidong WangWenhua SunMingjian Li

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2022)

This study shows that serum IGF-1 levels were correlated with the nonmotor symptoms of anxiety, depression, and cognitive dysfunction and that EGF levels were correlated with cognitive dysfunction. The combination of IGF-1 and EGF increased the value for a PD diagnosis. This is the first report of the simultaneous detection of IGF-1 and EGF levels to explore the correlation with nonmotor symptoms of PD.

Keyphrases

growth factor
sleep quality
parkinson disease
pi k akt
end stage renal disease
ejection fraction
growth hormone
depressive symptoms
chronic kidney disease
prognostic factors
patient reported outcomes
signaling pathway
deep brain stimulation
patient reported
sensitive detection