Increased regurgitant flow causes endocardial cushion defects in an avian embryonic model of congenital heart disease.
Stephanie M FordMatthew T McPheetersYves T WangPei MaShi GuJames StrainicChristopher SnyderAndrew M RollinsMichiko WatanabeMichael W JenkinsPublished in: Congenital heart disease (2017)
The data illustrate a strong inverse relationship in which regurgitant flow precedes abnormal and smaller cardiac cushions, resulting in the development of CHDs.