Genome-wide analysis reveals genetic overlap between alcohol use behaviours, schizophrenia and bipolar disorder and identifies novel shared risk loci.

Erik D WiströmKevin S O'ConnellNaz KaradagShahram BahramiGuy F L HindleyAihua LinWeiqiu ChengNils Eiel SteenAlexey ShadrinOleksandr FreiSrdjan DjurovicAnders M DaleOle A AndreassenOlav B Smeland

Published in: Addiction (Abingdon, England) (2021)

Alcohol use disorder and alcohol consumption share genomic loci with the psychiatric disorders schizophrenia and bipolar disorder with a mixed pattern of effect directions, indicating a complex genetic relationship between the phenotypes.

Keyphrases

bipolar disorder
genome wide
alcohol consumption
copy number
alcohol use disorder
major depressive disorder
genome wide analysis
dna methylation
genome wide association study
genome wide association
gene expression