Near-Infrared-Light Remote-Controlled Activation of Cancer Immunotherapy Using Photothermal Conjugated Polymer Nanoparticles.
Xuancheng FuYiming HuangHao ZhaoEndong ZhangQi ShenYufei DiFengting LvLibing LiuJianwu WangPublished in: Advanced materials (Deerfield Beach, Fla.) (2021)
Remote control of the therapeutic process is an ideal strategy for maximizing efficacy and avoiding side effects, especially for cancer immunotherapy. Herein, a conjugated polymer nanoparticles (CPNs)-mediated optogenetic system for in situ activation of immunotherapy under near-infrared laser irradiation is reported. This system is composed of photothermal CPNs and interferon-gamma (IFN-γ) plasmid driven by heat shock promoter HSP70. The photothermally responsive CPNs serve as a photo-heat nanotransducer to trigger the gene transcription of IFN-γ cytokine. The secreted IFN-γ from cancer cells can sufficiently elicit surrounding tumor-associated macrophages activation through IFN-γ-JAK-STAT1 transcription-factor signaling pathway and finally induce cancer cell killing by immunotherapy. Therefore, this synergetic optogenetic system provides a promising approach to remotely control the process of cancer immunotherapy.
Keyphrases
- heat shock
- dendritic cells
- transcription factor
- photodynamic therapy
- immune response
- heat stress
- cancer therapy
- signaling pathway
- heat shock protein
- drug delivery
- genome wide identification
- escherichia coli
- dna methylation
- drug release
- epithelial mesenchymal transition
- gene expression
- copy number
- genome wide
- pi k akt
- crispr cas
- endoplasmic reticulum stress
- radiation induced