Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir.
Yanmei HuEric M LewandowskiHaozhou TanXiaoming ZhangRyan T MorganXiujun ZhangLian M C JacobsShane G ButlerMaura V GongoraJohn ChoyXufang DengYu ChenJun WangPublished in: bioRxiv : the preprint server for biology (2022)
Paxlovid resistant SARS-CoV-2 viruses with mutations in the main protease have been identified from clinical isolates.