Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir.

Yanmei HuEric M LewandowskiHaozhou TanXiaoming ZhangRyan T MorganXiujun ZhangLian M C JacobsShane G ButlerMaura V GongoraJohn ChoyXufang DengYu ChenJun Wang

Published in: bioRxiv : the preprint server for biology (2022)

Paxlovid resistant SARS-CoV-2 viruses with mutations in the main protease have been identified from clinical isolates.

Keyphrases

sars cov
respiratory syndrome coronavirus
genetic diversity