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Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir.

Yanmei HuEric M LewandowskiHaozhou TanXiaoming ZhangRyan T MorganXiujun ZhangLian M C JacobsShane G ButlerMaura V GongoraJohn ChoyXufang DengYu ChenJun Wang
Published in: bioRxiv : the preprint server for biology (2022)
Paxlovid resistant SARS-CoV-2 viruses with mutations in the main protease have been identified from clinical isolates.
Keyphrases
  • sars cov
  • respiratory syndrome coronavirus
  • genetic diversity