Chitosan functionalized Mn 3 O 4 nanoparticles counteracts ulcerative colitis in mice through modulation of cellular redox state.
Susmita MondalMonojit DasRia GhoshManali SinghAniruddha AdhikariSoumendra DarbarAnjan Kumar DasSiddhartha Sankar BhattacharyaDebasish PalDebasish BhattacharyyaAhmed S A AhmedAsim Kumar MallickMunirah M Al-RooqiZiad MoussaSaleh A AhmedSamir Kumar PalPublished in: Communications biology (2023)
Recent findings suggest a key role for reactive oxygen species (ROS) in the pathogenesis and progression of ulcerative colitis (UC). Several studies have also highlighted the efficacy of citrate functionalized Mn 3 O 4 nanoparticles as redox medicine against a number of ROS-mediated disorders. Here we show that synthesized nanoparticles consisting of chitosan functionalized tri-manganese tetroxide (Mn 3 O 4 ) can restore redox balance in a mouse model of UC induced by dextran sulfate sodium (DSS). Our in-vitro characterization of the developed nanoparticle confirms critical electronic transitions in the nanoparticle to be important for the redox buffering activity in the animal model. A careful administration of the developed nanoparticle not only reduces inflammatory markers in the animals, but also reduces the mortality rate from the induced disease. This study provides a proof of concept for the use of nanomaterial with synergistic anti-inflammatory and redox buffering capacity to prevent and treat ulcerative colitis.
Keyphrases
- ulcerative colitis
- reactive oxygen species
- mouse model
- drug delivery
- quantum dots
- anti inflammatory
- dna damage
- cell death
- room temperature
- electron transfer
- iron oxide
- molecularly imprinted
- transition metal
- wound healing
- high glucose
- cardiovascular disease
- mass spectrometry
- cardiovascular events
- skeletal muscle
- adipose tissue
- high fat diet induced
- oxidative stress
- endothelial cells
- cancer therapy