Effect of blood collection tube containing protease inhibitors on the pre-analytical stability of Alzheimer's disease plasma biomarkers.

Yijun ChenXuemei ZengJihui LeeAnuradha SehrawatTara K LaffertyJames J BoslettWilliam E KlunkTharick A PascoalVictor L VillemagneAnnie D CohenOscar LopezNathan A YatesJonathan M Schott

Published in: medRxiv : the preprint server for health sciences (2024)

Supplementation of blood collection tubes with protease inhibitors could reduce the protease-induced degradation of plasma Aβ42 and Aβ40, and the Aβ ratio for IP-MS assay. This has crucial implications for preanalytical procedures, particularly in resource-limited settings.

Keyphrases

mass spectrometry
high glucose
ms ms
high throughput
cognitive decline
mild cognitive impairment
single cell