Synthesis of imidazo[1,5-a]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanes.

Dmitrii A Aksenov Nikolai A Arutiunov Vladimir V Maliuga Alexander V Aksenov Michael Rubin

Published in: Beilstein journal of organic chemistry (2020)

Imidazo[1,5-a]pyridines were efficiently prepared via the cyclization of 2-picolylamines with nitroalkanes electrophilically activated in the presence of phosphorous acid in polyphosphoric acid (PPA) medium.

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