Comparative Tumor Microenvironment Analysis of Primary and Recurrent Ovarian Granulosa Cell Tumors.
Eleonora Yu KhlebusVeena K VuttaradhiThomas WelteNamrata KhuranaJoseph CelestinoHannah C BeirdCurtis GumbsLatasha LittleAlejandra Flores LegarretaBryan M FellmanTri NguyenBarrett C LawsonSammy Ferri-BorgognoSamuel C MokRussell R BroaddusDavid M GershensonP Andrew FutrealRobert Tyler HillmanPublished in: Molecular cancer research : MCR (2023)
Recurrent aGCTs exhibit alterations in hormone pathway gene expression as well as decreased infiltration of cancer-associated fibroblasts, suggesting dual roles for hormonal signaling and TME remodeling underpinning disease relapse.