Monitoring sarcoma response to immune checkpoint inhibition and local cryotherapy with circulating tumor DNA analysis.

Nam Q Bui Neda Nemat-Gorgani Ajay Subramanian Ileana A Torres Marta Lohman Timothy J Sears Matt van de Rijn Gregory W Charville Hans-Christoph Becker David S Wang Gloria L Hwang Kristen N Ganjoo Everett J Moding

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

ctDNA represents a promising biomarker for monitoring response to treatment in advanced STS, warranting future prospective studies. Combining cryotherapy and immune checkpoint inhibitors did not increase the response rate of STSs to immunotherapy.

Keyphrases

circulating tumor
cell free
circulating tumor cells
current status
replacement therapy