Enhanced Antifungal Activity of WS2/ZnO Nanohybrid against Candida albicans.

Candida albicans forms persistent infections through the formation of biofilms that confer resistance to existing antifungal drugs. Biofilm targeting is therefore a promising strategy to combat Candida albicans infections. The WS2/ZnO nanohybrids exhibits considerably improved antibiofilm activity and inhibited the biofilm formation by 91%, which is quite better than that for pristine WS2, which is only 74%. The physical blend prepared by mixing WS2 nanosheets and WS2/ZnO in the ratio of 70:30 showed an antibiofilm activity of 58%, which was intermediate to that observed for pristine materials. The as-synthesized nanohybrid also demonstrates dose-dependent antifungal activity as calculated using the disc diffusion test. WS2/ZnO nanohybrid shows 1.5 times higher activity compared to pristine WS2 nanosheets suggesting that the nanohybrid materials are more effective as novel antifungal materials.