Polymeric Nitric Oxide Delivery Nanoplatforms for Treating Cancer, Cardiovascular Diseases, and Infection.
Guorui JinZhiyuan GaoYangjing LiuJing ZhaoHanlin OuFeng XuDan DingPublished in: Advanced healthcare materials (2020)
The shortened Abstract is as follows: Therapeutic gas nitric oxide (NO) has demonstrated the unique advances in biomedical applications due to its prominent role in regulating physiological/pathophysiological activities in terms of vasodilation, angiogenesis, chemosensitizing effect, and bactericidal effect. However, it is challenging to deliver NO, due to its short half-life (<5 s) and short diffusion distances (20-160 µm). To address these, various polymeric NO delivery nanoplatforms (PNODNPs) have been developed for cancer therapy, antimicrobial and cardiovascular therapeutics, because of the important advantages of polymeric delivery nanoplatforms in terms of controlled release of therapeutics and the extremely versatile nature. This reviews highlights the recent significant advances made in PNODNPs for NO storing and targeting delivery. The ideal and unique criteria that are required for PNODNPs for treating cancer, cardiovascular diseases and infection, respectively, are summarized. Hopefully, effective storage and targeted delivery of NO in a controlled manner using PNODNPs could pave the way for NO-sensitized synergistic therapy in clinical practice for treating the leading death-causing diseases.
Keyphrases
- cancer therapy
- nitric oxide
- drug delivery
- cardiovascular disease
- papillary thyroid
- small molecule
- squamous cell
- nitric oxide synthase
- hydrogen peroxide
- coronary artery disease
- staphylococcus aureus
- endothelial cells
- young adults
- type diabetes
- cardiovascular risk factors
- stem cells
- squamous cell carcinoma
- bone marrow
- cell therapy
- cardiovascular events