Sirtuin 2 deficiency aggravates ageing-induced vascular remodelling in humans and mice.
Yang ZhangXiaoman WangXun-Kai LiShuang-Jie LvHe-Ping WangYang LiuJingyue ZhouHui GongXiao-Feng ChenSi-Chong RenHuina ZhangYuxiang DaiHua CaiBo YanHou-Zao ChenXiaoqiang TangPublished in: European heart journal (2023)
The deacetylase SIRT2 is a response to ageing that delays vascular ageing, and the cytoplasm-mitochondria axis (SIRT2-p66Shc-mROS) is important for vascular ageing. Therefore, SIRT2 may serve as a potential therapeutic target for vascular rejuvenation.