Assessing the benefits and risks of amantadine for irritability and aggression after traumatic brain injury.

Flora M HammondRoss D ZafonteMark ShererKathleen R BellJennifer BognerJames F MalecQing TangJeong Hoon Jang

Published in: PM & R : the journal of injury, function, and rehabilitation (2023)

Clinician ratings suggest modest benefit of amantadine 100 mg twice daily with low risk to appropriately selected patients with adequate renal clearance. Thus, amantadine should be considered a treatment option for the experienced brain injury clinician. These data may support treatment decisions when a pharmaceutical agent is being considered to control irritability/aggression.

Keyphrases

brain injury
subarachnoid hemorrhage
combination therapy
risk assessment
machine learning
electronic health record
deep learning
big data
human health