H19 regulation of oestrogen induction of symmetric division is achieved by antagonizing Let-7c in breast cancer stem-like cells.

Meng WangYuan LiGuo-Dong XiaoXiao-Qiang ZhengJi-Chang WangChong-Wen XuSida QinHong RenShou-Ching TangXin Sun

Published in: Cell proliferation (2018)

Our results revealed a previously undescribed double negative feedback loop between sponge H19 and targeted Let-7c through oestrogen activated Wnt signalling that dominated in stem cells' division.

Keyphrases

stem cells
cancer therapy
cell proliferation
single cell
transcription factor
mesenchymal stem cells
young adults