Tumor-derived IL-8 facilitates lymph node metastasis of gastric cancer via PD-1 up-regulation in CD8 + T cells.
Xiang LiJing ZhaiYuke ShenTiancheng ZhangYaohui WangYani HeQiang YouLizong ShenPublished in: Cancer immunology, immunotherapy : CII (2022)
The present study elucidates the pro-metastatic role of elevated IL-8 in gastric cancer, and provides novel insights to enhance immune checkpoint blockade therapy for anti-PD-1 in gastric cancer.