Twice-Daily Dolutegravir Based Antiretroviral Therapy with One Month of Daily Rifapentine and Isoniazid (1HP) for TB Prevention.

Anthony T PodanyYoninah CramerMarjorie ImperialSusan L RosenkranzAnchalee AvihingsanonRoberto ArduinoWadzanai SamanekaIrina GelmanovaRada SavicSusan SwindellsRodney DawsonAnne F Luetkemeyer

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2024)

Dolutegravir trough concentrations with 50mg twice daily dosing during 1HP treatment were greater than those with standard dose dolutegravir once daily without 1HP. These pharmacokinetic, virologic, and safety data provide support for twice daily dolutegravir use in combination with 1HP for TB prevention.

Keyphrases

antiretroviral therapy
hiv infected patients
hiv infected
human immunodeficiency virus
physical activity
hiv positive
mycobacterium tuberculosis
hiv aids
electronic health record
hepatitis c virus
south africa