Crystal structure analysis of N-acetylated proline and ring-size analogs.
Tobias SchnitzerNils TrappHelma WennemersPublished in: Journal of peptide science : an official publication of the European Peptide Society (2022)
Crystal structures of N-acetylated proline and homologs with four- and six-membered rings (azetidine carboxylic acid and piperidine carboxylic acid) were obtained and compared. The distinctly different conformations of the four-, five-, and six-membered rings reflect Bayer strain, n→π* interaction, and allylic strain, and result in crystal lattices with a zig-zag structure.
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