Paternal hypoxia exposure primes offspring for increased hypoxia resistance.

Alexandria RagsdaleOscar Ortega-RecaldeLudovic DutoitAnne A BessonJolyn H Z ChiaTania KingShinichi NakagawaAnthony HickeyNeil J GemmellTimothy HoreSheri L Johnson

Published in: BMC biology (2022)

Overall, our findings suggest that an epigenetic memory of past hypoxia exposure is maintained and that this environmentally induced information is transferred to subsequent generations, pre-acclimating progeny to cope with hypoxic conditions.

Keyphrases

endothelial cells
high glucose
dna methylation
gene expression
high fat diet
working memory
healthcare
diabetic rats
type diabetes
drug induced
health information
oxidative stress
skeletal muscle